A comparative study of Botulinum toxin type A versus conventional oral therapy as a second-line treatment of diabetic neuropathy

Abstract Background Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Poor adherence to medication common in neuropathy mainly due side effects and poor tolerance medication. Botulinum toxin A intradermal injection has proved efficacy cases of neuropathy, however there a need compare its effect other lines treatment. The aim the study was type versus conventional oral treatment as second-line painful current comparative on 30 patients with 2 diabetes mellitus. Diabetic nerve conduction study. All were carbamazepine. Patients divided randomly into three groups. First group add-on duloxetine, second gabapentin third injected A. Results Our showed that injection, duloxetine therapy decreased VAS PSQI over 12-week period this statistically significant at p < 0.001*. also mean PSQ1 from 17.3 ± 1.8 10.9 3.1 12 weeks constituting highest decline among groups Conclusion had comparable if not superior